By Peter Beighton MD, PhD, FRCP, DCH, Rodney Grahame MD, FRCP, FACP, Howard Bird MD, MRCP (auth.), Rodney Grahame MD, FRCP, FACP (eds.)
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Extra resources for Hypermobility of Joints
The synthesis and polymerisation of collagen is a complex process involving many stages of modification after the component a chains have been synthesised in the cell. Here, the main steps in intracellular synthesis will be described, following by the extracellular events which lead to the formation of stable fibres . Biosynthesis Collagen molecules are synthesised as precursors, termed procollagens, consisting of a central helical portion (approximately 1000 amino acid residues long) with terminal globular regions (the amino and carboxyl pep tides) (Fig.
A similar result has been obtained by comparing the finger joints of different racial groups in southern Africa (Schweitzer 1970). The question of interethnic variation could be resolved by large-scale comparative studies employing the techniques discussed in this chapter. 's (1973) modification of the Carter and Wilkinson (1964) scale, the right (usually dominant) side being significantly less mobile than the left side, whatever the hypermobility score (Al-Rawi et al. 1985). Comparable data from an age-matched group of English university students has shown a 22 Assessment of Hypermobility lower prevalence of hypermobility using the same scoring system (Bird and Calguneri 1986).
Clin Biomech 1: 44-51 Poul J, Fait M (1986) Generalisierte Bandlaxitat bei Kindem. Z Orthop 124: 336-339 Poul J, Fait M (1989) Frequency of occurrence of generalised ligamentous laxity in a population of children. Reumatologia (CSSR), in press. Schober P (1937) Lendenwirbelsaul und Kreuzschmerzen. Miinchen Med Wochenschr 84: 336-339 Schweitzer G (1970) Laxity of metacarpophalangeal joints of finger and interphalangeal joint of the thumb: a comparative interracial study. S Afr Med J 44: 246-249 Silman AJ, Haskard D, Day S (1986) Distribution of joint mobility in a normal population: results of the use of fixed torque measuring devices.
Hypermobility of Joints by Peter Beighton MD, PhD, FRCP, DCH, Rodney Grahame MD, FRCP, FACP, Howard Bird MD, MRCP (auth.), Rodney Grahame MD, FRCP, FACP (eds.)