By Kenji Ikehara
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Additional info for Advances in the Study of Genetic Disorders
2008). , 2002). A positive association between kinship and fertility was found at all levels of kinship tested, although the differences between consanguineous and non-consanguineous couples were statistically significant only for first cousin couples. Since these positive associations between consanguinity and fertility could largely be due to uncontrolled sociodemographic variables, Bittles et al. (2002) performed an analysis based on data of first cousin marriages from the National Family and Health Survey conducted in India during 1992-1993.
However, it is very likely that Darwin also had a personal interest on this matter. Charles Darwin was married to his first cousin Emma Wedgwood and they had 10 children along their lifetime. Darwin was worried about the health of his children, who were very often ill and three of them died before adulthood. Darwin´s own ill health led him to fear that his children could have inherited his medical problems but he also suspected that his marriage to his first cousin might have caused some of his children´s health problems (Jones, 2008; Moore, 2005).
Autosomal recessive genetic disorders are not appeared into their children, if either parent has two normal genes on two chromosomes, and the disorders are inherited at a 25% chance if both parents are carriers of the disorder. Contrary to that, Huntington’s disease and neurofibromatosis caused by inheritance of the abnormal genes from either parent are inherited dominant manner. Therefore, each child has a 50% chance upon inheriting the genetic disorder, if just one parent has a dominant gene defect.
Advances in the Study of Genetic Disorders by Kenji Ikehara